Abstract
Negative pressure pulmonary edema is a rare form of non-cardiogenic pulmonary edema triggered by various factors, potentially and rapidly leading to severe respiratory distress. We report the case of a 15-year-old patient who developed NPPE secondary to acute laryngospasm during extubation after an uncomplicated appendectomy. Supportive treatment, including oxygen therapy and airway stabilization, resulted in rapid clinical improvement. This condition is typically caused by the generation of markedly negative intrathoracic pressure against an obstructed upper airway, leading to fluid transudation into the alveoli. Although uncommon, prompt recognition is essential to ensure appropriate management and avoid unnecessary interventions, as most cases resolve rapidly with supportive care.

